Yes, progesterone has an effect on acne. High progesterone levels in women that occur during the menstrual periods lead to increase in acne, with birth control pills having negative effects on pimples. It is to be understood that progesterone does not in itself cause pimples and acne, but its part androgenic effect plays a role. The same is the case with menopausal women that experience such symptoms.
It is to be also realized that natural progesterone cream used by the middle-aged women has mixed reactions with some claiming removal of acne blemishes on use, while others complain of pimple aggravation. It is also advisable for you to consult a licensed physician first before starting to use any particular progesterone cream available online or over the counter.